摘要
目的：探讨非洛地平对家兔血管成形术后内皮功能及内膜增殖的影响。方法：日本大耳白兔３６只，高脂喂养４周后用球囊导管剥脱腹主动脉内皮，再高脂喂养４周后，对动脉粥样硬化部位行血管成形术，３０只成功的动物随机分为对照组、高脂组和治疗组（非洛地平），继续喂养４周后采集局部血管行病理形态学分析，并观察实验前后各组血清脂质、一氧化氮及血浆内皮素－１的改变。结果：治疗组血管内膜面积与中膜面积之比及内膜面积均降低。各组高脂饮食后血清总胆固醇、甘油三酯和血浆内皮素－１均明显升高，而血清一氧化氮明显下降；１２周治疗组血浆内皮素－１明显降低，而血清一氧化氮水平明显升高。结论：非洛地平具有抑制家兔血管成形术后内膜增殖和保护内皮功能的作用。
Objective:To investigate the effects of felodipine on endothelial function and neointimal proliferation after angioplasty of the rabbits. Methods:The celiac arterial endothelium of 36 male Japanese white rabbits were denuded after being fed with high cholesterol diet for 4 weeks,and the angioplasty to atherosclerotic stenosis of celial arteries was performed after 4 addtional weeks of high cholesterol diet.30 successful animals were randomized to the control group,high cholesterol group and felodipine group.In continuous 4 weeks later,the local vessels were collected for morphological observation,and blood lipid.Nitric oxide (NO)and endothelin 1(ET 1)were also meassured during this experiment. Results:The morphological ohservation showed that the neointimal area(NEA)and neointimal to medial area ratio(NEA/MA)in felodipine group were less than the control group,and those in control group were less than in high cholesterol group.The serum total cholesterol(TC)、triglyceride (TG)and ET 1 levels were increased and the serum NO level had a tendency to decrease after high cholesterol diet.However in comparision to the control group,there were apparently decreased TC、TG and ET 1 levels and increased NO level in felodipine group. Conclusion:The felodipine had the effects of inhibiting the neointimal proliferation and of protecting the endothelial function after angioplasty in rabbits.
出处
《中国循环杂志》
CSCD
北大核心
1999年第2期78-80,共3页
Chinese Circulation Journal
关键词
非洛地平
血管成形术
内皮功能
内膜增殖
Felodipine
Angioplasty
Endothelial function
Neointimal proliferation
