摘要
目的:探讨补肾健脾消症方对胃癌术后患者化疗过程中细胞免疫功能和生存质量的影响。方法:将60例胃癌术后患者随机分为单纯化疗组和联合化疗组各30例,并与健康对照组比较,观察化疗前后NK细胞活性、CD3+、CD4+、CD8+、CD4+/CD8+比值,以及生存质量评分(Karnofky评分)情况。结果:1、与健康对照组比较,胃癌术后患者NK细胞活性、CD3+和CD4+显著降低(P<0.05),而CD8+明显升高(P<0.05),致CD4+/CD8+比值降低(P<0.01);2、同组治疗前后比较,单纯化疗组治疗后NK细胞活性、CD3+降低明显(P<0.05)。两组治疗后比较,联合化疗组NK细胞活性、CD8+高于单纯化疗组(P<0.05),在CD3+、CD4+、CD4+/CD8+比较上差异更为明显(P<0.01);3、同组治疗前后比较,联合化疗组治疗后Karnofky评分明显高于治疗前(P<0.05),而单纯化疗组治疗前后无明显变化。两组治疗后比较,联合化疗组Karnofky评分明显高于单纯化疗组(P<0.01)。结论:补肾健脾消症方可显著提高胃癌术后患者化疗过程中的细胞免疫功能和生存质量。
Objective：To explore the Bushenjianpixiaozheng （BSJPXZ） prescription in patients with operation chemotherapy process and quality of life of the cellular immune function. Methods：60 cases were randomly divided into pure chemotherapy group and combination chemotherapy groups. Compared with healthy group,and observe the NK cell activity and ratio of CD3^＋,CD4^＋,CD8 ＋,CD4^＋ / CD8^＋ ,and quality of life score （Karnofky score）. Results：First,Compared with healthy controls,NK cell activity ,CD3^＋,CD4 ＋ significantly reduced （P〈0.05）,and CD8^＋ increased significantly （P 0.05）,cause CD4 ＋ / CD8^＋ ratio lower （P〈0.01）. Second,the comparison group before and after treatment,the pure chemotherapy group after treatment,CD3^＋,NK cells activity reduced significantly （P〈0.05）. Two groups after treatment with combination chemotherapy group,NK cell activity,CD8^＋ higher than pure chemotherapy group （P〈0.05）,CD3^＋,CD4^＋,CD4^＋ / CD8^＋ is more obvious difference （P〈0.01）.Third,before and after the treatment group,combination chemotherapy treatment group was obviously higher than the pure chemotherapy group has no obvious changes before and after treatment by Karnofky score （P〈0.05）. Two groups after treatment with combination chemotherapy group,Karnofky score significantly higher than the pure chemotherapy group （P〈0.01）. Conclusion：BSJPXZ prescriptioncan significantly improve the process of chemotherapy patients after operation in cellular immune function and quality of life.
出处
《中华中医药学刊》
CAS
2010年第8期1781-1783,共3页
Chinese Archives of Traditional Chinese Medicine
