摘要
目的探讨补肾软坚方治疗多囊卵巢综合征(PCOS)无排卵症的疗效及作用机制。方法选择58例PCOS无排卵症患者,随机分成治疗组(29例)采用补肾软坚方治疗,对照组(29例)用克罗米芬治疗,均治疗3个月经周期。观察两组临床疗效、中医证候改善情况、血清性激素水平的变化等。结果治疗组和对照组疾病疗效总有效率分别为72.4%和69.0%,两组疾病疗效差异无统计学意义(P>0.05)。治疗组中医证候疗效有效率为93.1%,对照组为75.9%,两组疗效比较差异有统计学意义(P<0.05)。治疗组治疗后LH、T、LH/FSH值均较治疗前降低(P<0.05,P<0.01);治疗组治疗后血清E2升高,与对照组比较,差异有统计学意义(P<0.01)。结论补肾软坚方治疗PCOS无排卵症有良好疗效,其作用机制与调节性激素水平有关。
Objective To study the effects of ＂Bushen Ruanjian Formula＂ on polycystic ovary syndrome（PCOS） with anovulation and investigate its therapeutic mechanisms. Methods Fifty-eight PCOS patients with anovulation were randomly divided into treatment group and control group, respectively treated with ＂Bushen Ruanjian Formula＂ and clomifene. The clinical symptoms and signs, and serum sex hormone level were observed before and after therapy. Results The total effective rates in the treatment group and control group were 72.4% and 69.0% respectively, with no significant difference in clinical effect between the two groups（ P 〉 0.05） . The TCM syndrome efficacy in the treatment group was 93.1%, higher than 75.9 % in the control group （ P 〈 0.05 ）. In the treatment group, the levels of luteinizing hormone, testosterone, and the ratio of LH/FSH after treatment were lower than those before treatment（P 〈0.05, P 〈0.01 ）. And there was a significant difference in the contents of estradiol between groups （P 〈 0.01 ）. Conclusion ＂Bushen Ruanjian Formula＂ may be effective in treating PCOS with anovulation by regulating the sex hormone.
出处
《上海中医药杂志》
2010年第8期47-50,共4页
Shanghai Journal of Traditional Chinese Medicine
关键词
多囊卵巢综合征
无排卵症
补肾软坚方
克罗米芬
Polycystic ovary syndrome
anovulation
＂Bushen Ruanjian Formula＂
clomifene
