摘要
目的:观察水针联合托烷司琼预防顺铂致延迟性呕吐的效果。方法:67例晚期非小细胞肺癌(NSCLC)患者均接受含顺铂双药化疗(NP、GP、TP方案),随机分为2组。联合水针组(35例):足三里注射地塞米松5mg qd,静脉注射托烷司琼5mg bid;托烷司琼组(32例):静脉注射托烷司琼5mg bid。结果:两组急性呕吐的完全缓解率和有效控制率无显著差异(P﹥0.05),延迟性呕吐的完全缓解率和有效控制率差异显著(P<0.05)。最常见的不良反应都是头痛、眩晕、腹胀、便秘,联合水针组腹胀、便秘发生率较低。结论:水针联合托烷司琼能有效预防顺铂致延迟性呕吐,且消化道不良反应发生率低。
Objective: To evaluate the clinical effects of water injection plus tropisetron regimen in preventing delayed vomiting induced by cisplatin.Methods All the patients with advanced NSCLC were divided randomly into two groups,whom were given combined chemotherapy plus cisplatin(NP、GP、TP regimen).Regimens: Treatment group(35 cases) :water injection treatment was used and the drug was used as same as the tropisetron group.Tropisetron group: tropisetron 5 mg,iv,every 12h.Results For vomiting during the acute phase,complete response rates of treatment group and tropisetron group were 94.29% and 90.63% respectively,with an overall response rates of 100% and 96.88% respectively,of which the difference was insignificant(P﹥ 0.05).For delayed phase,complete response rates of treatment group and tropisetron group were 57.14%~85.71% and 18.75%~28.13% respectively,and that,overall response rates were 85.71%~100% and 43.75%~78.1% respectively,of which the difference was significant(P0.05).Common side effects included headache,vertigo,abdominal distension and constipation.The incidence rates of abdominal distension and constipation in treatment group were lower than tropisetron group.Conclusion Water injection plus tropisetron regimen was effective in preventing delayed vomiting induced by cisplatin,furthermore,the incidence rates of digestive canal were low.
出处
《中医药学报》
CAS
2010年第4期97-99,共3页
Acta Chinese Medicine and Pharmacology
关键词
水针
托烷司琼
顺铂
延迟性呕吐
Water injection
Tropisetron
Cisplatin
Delayed vomiting