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病理学检查在宫颈上皮内瘤变诊断中的应用体会 被引量:6

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摘要 目的探讨病理学检查方法在宫颈上皮内瘤变诊断中的价值。方法收集我院妇产科患者1150例行TCT检查,其中165例应用杂交捕获技术(HC-II)检测HR-HPV;104例细胞学阳性者行阴道镜下宫颈活检;采用SP法检测58例宫颈各类病变中的P16蛋白表达;以病理学为标准,比较各种方法对宫颈病变的诊断价值。结果①TCT阳性率明显高于传统的巴氏涂片;②HR-HPV检测随着CIN病变的加重,HR-HPV阳性率增加(P<0.01);③阴道镜下宫颈活检细胞阳性检出率明显高于TCT阳性检出率(P<0.01);④P16可作为NILM与CINI级,CINI级与CINII-III级间鉴别诊断的标记物。结论病理学检查各种方法都各自具有优点和局限性,相互不能替代,相互结合可以最大限度弥补相互的缺点,提高宫颈病变诊断的准确性。
作者 徐伟莉
出处 《中国实用医药》 2010年第23期106-108,共3页 China Practical Medicine
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