摘要
雌激素受体包括两大类:一是经典的核受体,包括ERα和ERβ,它们位于细胞核内,介导雌激素的基因型效应,即通过调节特异性靶基因的转录而发挥"基因型"调节效应;二是膜性受体,包括经典核受体的膜性成分以及属于G蛋白偶联受体家族的GPER1(GPR30)、Gαq-ER和ER-X,它们介导快速的非基因型效应,通过第二信使系统发挥间接的转录调控功能,其中一些似乎只在脑局部起作用。这两类受体在机体内的分布具有组织/细胞特异性,参与了对诸如生殖、学习、记忆、认知等多种功能的调节。
Estrogen receptors can be classified as classic nuclear receptors and novel non-classic membranous receptors.The former includes the well-known α（ERα） and β（ERβ） subtypes,which are located in cell nucleus and mediate genomic effects of estrogen by regulating the transcription of specific target genes.The membranous receptors,including G protein-coupled receptor 30（GPER1,also called GPR30）,Gαq-ER and ER-X and the extra-nuclear components of the classical ERs,were identified in recent years and it seems that some of them only function in specific brain regions.These membranous receptors mediate rapid non-genomic actions by interaction with the second message cascade.All these ERs have been identified and function in different organs in a cell/tissue-dependent manner.
出处
《生命的化学》
CAS
CSCD
北大核心
2010年第4期590-594,共5页
Chemistry of Life
基金
重庆市回国人员启动基金(No2007BB5030)
第三军医大学回国人员启动基金(No2007XG41)项目资助
关键词
雌激素
雌激素核受体
雌激素膜性受体
estrogen
nuclear estrogen receptor
membranous estrogen receptor
