摘要
目的:探讨螺内酯对无症状左室收缩功能障碍患者心室重构的影响。方法:入选我院2007-12-2009-06门诊及住院无症状左室收缩功能障碍[左室射血分数(LVEF)<40%,左室舒张末期容积指数(LVEDVI)>75ml/m2,纽约心脏病协会心功能分级Ⅰ级]患者63例,在常规治疗的基础上随机分为螺内酯干预组32例(螺内酯40mg/d),对照组31例,所有患者在入选前及药物应用6个月后行超声心动图检查评估LVEDVI、左室收缩末期容积指数(LVESVI)、左室质量指数(LVMI)和LVEF的变化。结果:治疗6个月后,2组LVEDVI、LVES-VI、LVMI和LVEF均较治疗前有明显改善,且差异有统计学意义(均P<0.05),螺内酯组改善更为显著(均P<0.05)。结论:在常规治疗的基础上加用螺内酯治疗可进一步改善无症状左室收缩功能障碍患者的心室重构。
Objective：To investigate the effect of spironolactone on ventricular remodeling in patients with asymptomatic left ventricular systolic dysfunction.Method：There were 63 patients with asymptomatic left ventricular Systolic Dysfunction （left ventricular ejection fraction40%,left ventricular end diastolic volume index75 ml/m2,New York Heart Association classⅠ） were enrolled in our hospital from the december of 2007 to the june of 2009.Spironolactone 40 mg/d was randomly administered in addition to the routine treatment for 32 patients.All the patients were examined echocardiography to assess left ventricular end diastolic volume index （LVEDVI）,left ventricular end systolic volume index （LVESVI）,left ventricular mass index （LVMI） and left ventricular ejection fraction （LVEF） before treatment and 6 months after treatment.Result：In the 6 months after treatment,LVEDVI,LVESVI,LVMI and LVEF were ameliorated obviously in the two groups （P〈0.05）.Spironolactone group was ameliorated more significantly （P〈0.05）.Conclusion：Spironolactone was adminstered in addition to the routine treatment for patients with asymptomatic left ventricular systolic dysfunction to advance ameliorating ventricular remodeling.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2010年第7期526-529,共4页
Journal of Clinical Cardiology
关键词
心力衰竭
螺内酯
心室重构
heart failure
dpironolactone
ventricular remodeling
