摘要
目的:观察不同剂量氟伐他汀早期治疗急性心肌梗死患者,对血清炎性因子、凝血4项的影响。方法:53例急性心肌梗死患者分为A、B2组。A组(27例)口服氟伐他汀40mg/d,B组(26例)口服氟伐他汀80mg/d,治疗前后分别测高敏C反应蛋白(hs-CRP)、可溶性白细胞分化抗原40配体(sCD40L)、基质金属蛋白酶-9(MMP-9)和凝血4项,随访3个月和6个月。结果:A和B组患者血清hs-CRP、sCD40L、MMP-9在治疗后3个月和6个月后均有明显下降(P<0.05),且B组较A组更明显。A组凝血酶原时间、部分凝血活酶、纤维蛋白原、凝血酶时间在治疗后3个月和6个月后无明显改变(P>0.05);B组凝血酶原时间、部分凝血活酶、凝血酶时间在治疗后3个月和6个月后明显延长,且纤维蛋白原明显降低(P<0.05)。结论:急性心肌梗死早期使用氟伐他汀可抑制患者炎性反应,且大剂量同时具有抗凝作用。
Objective：To observe the effects of different doses of Fluvastatin on the inflammatory markers and fibrinolysis analysis in acute myocardial infarction patients.Method：53 patients with acute myocardial infarction were divided into 2 groups （group A and B）.the group A （27 patients） were admitted orally Fluvastatin 40 mg/d and the group B （26 patients） were admitted orally Fluvastatin 80 mg/d.The serum levels of high sensitivity C reactive protein （hs-CRP）,soluble CD40 ligand （sCD40L）,matrix metalloproteinase-9 （MMP-9） and fibrinolysis analysis were measured at the end of the 3th month and the 6th month.Result：In group A and B,the serum levels of hs-CRP,sCD40L,MMP-9 were significantly decreased at the end of the 3th month and the 6th month （P0.05）.And the group B was superior to group A （P0.05）.In the groupA there is no significant difference in fibrinolysis analysis after treatment with Fluvastatin （P0.05）,but fibrinolysis analysis is significantly different in the group B at the end of the 3th month and the 6th month.Conclusion：The serum level of hs-CRP,sCD40L,MMP-9 were significantly decreased in acute myocardial infarction patients treated with Fluvastatin,and the high dose of Fluvastatin also had anticoagulant effect.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2010年第7期504-506,共3页
Journal of Clinical Cardiology
关键词
心肌梗死
氟伐他汀
炎性因子
纤溶4项
myocardial infarction
fluvastatin
inflammatory markers
fibrinolysis analysis
