摘要
目的：探讨丙型肝炎病毒（ＨＣＶ）基因型与干扰素治疗后ＨＣＶＲＮＡ阴转远期效果的相关性．方法：采用反转录ＰＣＲ（ＲＴ－ＰＣＲ）方法．结果：干扰素治疗后，经过１８ｍｏ～２６ｍｏ的随访，Ⅱ／１ｂ型ＨＣＶＲＮＡ持续阴转率为２０．０％（４／２０）；Ⅲ／２ａ型为７０．０％（７／１０），两型疗效相差非常显著（Ｐ＜０．０１）．结论：干扰素治疗丙型肝炎的疗效与丙型肝炎病毒基因型有关，对Ⅲ／２ａ型的疗效优于Ⅱ／１ｂ．
AIM: The study was to explore the interrelationship between genotype of hepatitis C virus and longterm therapeutic effect of HCVRNA negative after interferon treatment. METHODS: Reverse transcription polymerase chain reaction(RTPCR) was used to determinate HCVRNA in serum samples from 30 patients with hepatitis C. RESULTS: After 1826 months' interferon treatment,HCVRNA was continuously negative in 20% (4/20) of those with /1b type while 70% (7/10) in those with /2a type. The difference was significant. CONCLUSION: Therapeutic effect of interferon treating hepatitis C was related to HCV genotype and /2a group was much better than /1b group.
出处
《第四军医大学学报》
1999年第4期326-327,共2页
Journal of the Fourth Military Medical University
关键词
丙型肝炎
药物疗法
干扰素
hepatitis C virus
HCVRNA
genotype
interferon
