摘要
目的分析男性原发性胆汁性肝硬化(PBC)患者的临床特征及预后。方法回顾性分析19例男性PBC患者的临床资料。结果本组患者平均年龄54±17岁,其中17例(89%)为中老年;确诊时无症状者为7例(36.7%),失代偿期肝硬化9例(47.4%);100%患者血GGT和ALP升高,78.9%ALT和AST轻中度升高;2例(10.5%)合并干燥综合征;13例(68.4%)患者AMA阳性,14例(73.7%)AMA-M2阳性。经熊去氧胆酸治疗,早期患者病情有不同程度的好转。结论男性PBC患者起病隐匿,特异性自身抗体检测阳性率略低,早期诊断困难较大。
Objective To evaluate the clinical features,laboratory tests in male patients with primary biliary cirrhosis（PBC）. Methods The clinical data of 19 cases were analyzed retrospectively. Results 17 cases（89%）were middle-elderly aged with mean age of 54±17yr;7 case（s36.7%）were asymptomatic,and 9 case（s47.7%）were decompen- sated hepatic cirrhosis;The AMA in 13 patient（s68.4%）and AMA-M2 in 14（73.7%）were positive;With ursodeoxycholic acid treatment,patients in early stage improved. Conclusion Male patients with PBC have relatively mild clinical symptoms and low autoantibodies,which make the early diagnosis even hard.
出处
《实用肝脏病杂志》
CAS
2010年第4期282-283,共2页
Journal of Practical Hepatology
