摘要
目的：了解大剂量维生素Ｂ６在实验性动脉粥样硬化的保护作用与免疫因素的关联。方法：测定实验性高胆固醇家兔血清抗单核细胞抗体，以及白细胞移动抑制试验。结果：１）维生素Ｂ６有明显降低血胆固醇，减少动脉壁粥样斑块形成的作用；２）较长期喂胆固醇饲料，导致家兔细胞免疫反应下降，补充维生素Ｂ６可使细胞免疫反应维持原有水平；３）在无外来抗原诱导，较长期喂养高胆固醇饲料，可使家兔产生抗单核细胞抗体。结论：补充大剂量维生素Ｂ６可降低血胆固醇及减少动脉壁粥样斑块的形成，并能改善家兔细胞免疫状态，但未发现影响机体体液免疫。
Aim: This study was performed to investigate the immune state and the protective role with large-dose vitamin B6 in experimental atherosclerosis. Methods: Autoantibody aganist monocyte antign(ABC-ELISA) and cell-mediated (leukocyte migration inhibition test)were tested in experimental rabbits. Results: 1)Large-dose vitamin B6 supplementation showed significantly a reduction of serum cholesterol and decreasing formation of plaques on intima. 2) A reduction of cell-mediated immunity was found in artherosclerostic rabbits and supply of Vit.B6 may maintain its immunity to normal level.There were autoantibodies aganist monocyte antigens produced without receiving any exogenous antigen,both in cholesterol group and cholesterol+Vit. B6 group of test rabbits.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1999年第2期19-24,共6页
Journal of Jinan University(Natural Science & Medicine Edition)
关键词
维生素B6
动脉粥样硬化
免疫功能
保护作用
vitaminB6
experimental atherosclerosis model
antibody aganist monocyte antigen
leukocyte migration nhibition test.
