摘要
目的：探讨佝偻病的２５羟基胆骨化醇与甲状旁腺素的相关性。方法：测定１００例佝偻病患者２５羟基胆骨化醇与甲状旁腺素浓度，并对１０例未使用ＶｉｔＤ的激期患儿肌注ＶｉｔＤ３３０万ｕ，１５ｄ及２月后复查。结果：２５ＯＨＤ３明显低于正常组，随着病情加重而降低，ＰＴＨ高于正常组，但不随着病情加重而升高。肌注ＶｉｔＤ３１５ｄ复查２５ＯＨＤ３迅速升高，２月时仍持续较高水平，而ＰＴＨ无明显变化。结论：（１）佝偻病时２５ＯＨＤ３与ＰＴＨ具有一定相关性，其发病的关键是ＶｉｔＤ３活性代谢产物缺乏引起；（２）２５ＯＨＤ３在早期诊断是一敏感指标；（３）没有必要在短期内反复多次注射大剂量ＶｉｔＤ３。
Objective:To study the relevance between 25 hydroxyl cholecalciferol(25 OH D 3) and parathormone(PTH). Method:The levels of serum 25 OH D 3 and PTH were measured in 100 rickets patients. 10 patients at activated period and had never recieved VitD were treated by intramuscular injection Vit D 3, 25 OH D 3 and PTH were measured serially after 15 d and 2 m.Results: The level of 25 OH D 3 in rickets patients decreased abnormally and progressing lower as the patient's condition worsen. PTH level increased abnormally but it was not related with the patient's Condition. 25 OH D 3 level increased rapidly after 15 d Vit D 3 injection, These effect sustained to 2 m. The changes of PTH were insignificant. Conclusion:(1)They were certain relevance between 25 OH D 3 and PTH in rickets patients; (2) 25 OH D 3 was a sensitive marker for early diagnosis;(3)As to avoiding Vit D intoxication, it is not necessary to used large doses repeatedly in a short period.
出处
《江西医药》
CAS
1999年第1期14-15,共2页
Jiangxi Medical Journal
