摘要
目的了解足月新生儿缺氧缺血性脑病(HIE)血小板参数的变化及临床意义。方法选择2001年1月-2008年7月间,在株洲市人民医院治疗的足月新生儿缺氧缺血性脑病90例,其中轻度34例,中度30例,重度26例,同时与足月正常新生儿45例作对比,检测缺氧缺血性脑病急性期、恢复期血小板数(PLT)、血小板平均容积(MPV)、血小板分布宽度(PDW)的变化,并对照。结果足月新生儿缺氧缺血性脑病急性期PLT较对照组明显下降(P<0.01),MPV、PDW则明显升高(P<0.05),随病情加重,前者愈低,后两者愈高,而恢复期,检测结果与对照组间则差异无统计学意义。结论血小板参数可作为判断该病严重与否的参数指标,并监测病情变化。
Objective To investigate the changes of platelet parameters and its clinical significance in full-term neonates with hypoxic ischemic encephalopathy（HIE）.Methods Ninety full-term neonates with hypoxic ischemic encephalopathy hospitalized in the People＇s Hospital of Zhuzhou from January,2001 to July,2008 were enrolled into the study,including 34 neonates with mild HIE,30 neonates with moderate HIE,and 26 neonates with severe HIE.At the same time,45 normal full-term newborns were served as the control group.The changes of platelet count（PLT）,mean platelet volume（MPV）,and platelet distribution width（PDW）during the acute period and recovery period of hypoxic-ischemic encephalopathy were observed and then compared between the two groups.Results PLT level of full-term neonates with HIE during the acute period was significantly decreased as compared with that of control group（P〈0.01）,while the levels of MPV and PDW of full-term neonates with HIE during the acute period were significantly increased（P〈0.05）.The more severe the disease was,the lower the PLT level and the higher the MPV and PDW levels were.But no statistically significant difference was found in the detection results during the recovery period between the two groups.Conclusions Platelet parameters can be used as the indicators to judge the severity of the disease and monitor the changes of patient＇s condition.
出处
《实用预防医学》
CAS
2010年第8期1659-1660,共2页
Practical Preventive Medicine
