摘要
急性脑梗死是神经系统的常见病,是当前世界上三大主要死亡疾病之一,致死率和致残率高,已成为严重的医学和公共卫生课题,脑梗死急性期的治疗直接影响预后,所以寻找有效的治疗方法特别重要。近年来,国外普遍开展了溶栓治疗急性脑梗死的临床研究,许多结果表明,早期溶栓可能是治疗急性脑梗死最有效、最有希望的方法,它可迅速恢复梗死区脑血流量,使脑血管获得早期再灌注,使局部脑缺血造成的神经功能缺损症状和体征得以缓解。文献报道溶栓治疗的溶通率为21%～93%。但由于溶栓疗法引起的颅内出血、再灌注损伤和再闭塞等严重并发症,所以选择最佳溶栓方案、最适宜的溶栓时机和最佳给药途径以及理想的溶栓剂,成为当今世界溶栓疗法研究的主题。本文就急性脑梗死溶栓治疗的时间窗、方法的应用、并发症展望等方面进行了综述。
The acute cerebral infarction （acute cerebral infarction, ACI） which is the nervous system of common diseases is currently the one of the three major killer disease in world. Its high fatality rate and disability has become a serious medical and public health issue. As acute cerebral infarction directly affect the prognosis of the treatment period, so to find effective treatments has become especially important. In recent years, foreign countries have launched a thrombolytic-therapy clinical studies for acute ischemie stroke, many results indicate that early thrombolytie treatment of acute cerebral infarction may be the most effective and promising way to quieldy restore infarcted cerebral blood flow and make the brain vascular access to early reperfusion, so that the symptoms and signs in neurological deficit caused by focal cerebral isehemia can be alleviated. In thrombolytie therapy it is reported in the literature that melting pass rate was 21%-93%. However, because of intraeranial hemorrhage caused by thrombolytie therapy, reperfusion injury and re-occlusion and other severe complications of thrombolytie therapy program, to select the best and most appropriate timing of thrombolytie therapy and the best route of administration, as well as the ideal thrombolytie agent have become the hot spot of thrombolytie therapy. The time window, method of application, complications outlook, etc about thrombolytie therapy in acute cerebral infarction are summarized below.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第13期2027-2030,共4页
China Journal of Modern Medicine
关键词
急性脑梗死
溶栓时间窗
静脉溶栓
动静脉溶栓
动脉溶栓
并发症
acute cerebral infarction
time window of thrombolytic therapy
intravenous thrombolysis
arterio-venous thrombolysis
arterial thrombolysis
complications
