摘要
目的比较氩氦刀治疗荷瘤兔前、后的T淋巴细胞亚群的变化,探讨氩氦刀治疗荷瘤兔T细胞免疫的早期影响。方法①将30只荷瘤兔随机分为3组,氩氦刀治疗组(A组)、手术切除组(B组)、肿瘤对照组(C组)。②测定治疗前、后外周血T淋巴细胞亚群。结果 T细胞淋巴亚群结果 (Th、TS及Th/Ts):CD4(Th):A组有明显增加(P<0.05),B、C组有明显下降(P<0.05)。CD8(Ts):A、B、C组均有明显减低(P<0.05)。CD4/CD8(Th/Ts):A组有明显升高(P<0.05),B、C组无明显变化(P<0.05)。结论从T淋巴细胞亚群指标分析,A组早期的细胞免疫效应好于手术切除组。
Objective To discuss the early impact of cryosurgery ablation on the function of T cellular immunity in tumor-bearing rabbits through observing the changes of T cell subsets after cryosurgery procedure in experimental rabbits.Methods ① Thirty tumor-bearing rabbits were randomly and equally divided into 3 groups：group A,receiving cryosurgical treatment;group B,receiving surgical resection;and group C,used as control group.②Both the preoperative and the postoperative peripheral blood T cell subsets were determine in all experimental rabbits of three groups,the results were compared and statistically analyzed.Results After the procedure,CD8 was significantly decreased in all three groups（P〈0.05）.CD4 showed an obvious increase in group A（P〈0.05）,while a marked decrease in both group B and group C（P〈0.05）.The ratio of CD4 /CD8 showed a distinct elevation in group A（P〈0.05）,while no change in both group B and group C.Conclusion The results of this study indicates that cryosurgical ablation is superior to the surgical resection in enhancing the early effect of cell-mediated immunity.
出处
《介入放射学杂志》
CSCD
北大核心
2010年第7期558-559,共2页
Journal of Interventional Radiology
基金
江苏省“六大人才高峰”资助项目(2005A2)
关键词
荷瘤兔
氩氦刀
T细胞
tumor-bearing rabbit
cryosurgery
T cell
