摘要
目的:评价血清胱抑素C在不同程度肾积水肾功能损害诊断中的临床意义。方法:用ELISA法测定不同程度肾积水患者血清胱抑素C同时用酶法检测这些患者血清肌酐(Scr)、尿素氮(BUN)。以放射性核素99mTc-DTPA测得的肾小球滤过率(GFR)作为诊断评价的金标准。结果:轻度肾积水、中度肾积水、重度肾积水患者两两间血清有显著差异(P<0.01),且均与对照组有显著差异(P<0.01);不同程度肾积水患者血清胱抑素C、Scr、BUN均与GFR有相关性(P<0.01),胱抑素C与GFR相关系数最大(P<0.01)。结论:血清胱抑素C可作为单独评价GFR的敏感性指标,为检测肾功能提供了精确、可靠的指标。
Objective： To evaluate the applicability of serum cystatin C in patients with different degrees of hydronephrosis and with renal impairment.Methods： The value of serum cystatin C was measured by enzyme linked immunosorbent assay（ELISA）,serum creatinine（Scr） and blood urea nitrogen（BUN） were measured by method of enzyme,and glomerular filtration rate（GFR） was determined by 99mTc-DTPA clearance as a Gold Standard.Results： The value of serum cystatin C is significantly different among degrees of hydronephrosis and normal one（P〈0.01）.GFR was correlated with serum cystatin C,Scr,and BUN（P〈0.01）.Conclusion： Level of serum of cystatin C is a sensitive marker that relates to GFR.The value of serum cystatin C is a sensitive and reliable index for the evaluation of renal function.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2010年第4期499-501,共3页
Medical Journal of Wuhan University
