摘要
目的研究RhoA蛋白在喉癌组织、癌旁组织的表达情况,探讨其与喉癌的发生、发展以及转移之间的关系。方法采用免疫组织化学染色法检测喉癌组织及癌旁组织RhoA蛋白的表达及分布情况。结果喉癌内组织RhoA蛋白表达的阳性率为60.8%,高于癌旁组织的19.8%(P<0.01);高分化鳞癌组织RhoA蛋白表达阳性率为50.0%,低于中低分化鳞癌的86.7%(P<0.05)。结论 RhoA蛋白表达在喉癌的发生、发展的机制中起到促进作用,有可能对预测喉癌的发生、发展以及预后有一定价值。
Objective To study the expression of RhoA protein in human laryngeal carcinoma and periphery region, and explore the correlation between RhoA protein and laryngeal carcinoma. Methods The expression of RhoA protein was examined with immunohistochemical method in human laryngeal carcinoma. Results It was shown that the positive rate of RhoA protein in human laryngeal carcinoma was significantly higher than that in periphery region. The positive rate of RhoA in well-differentiated tissues was significantly higher than that of moderately or poorly differentiated tissues. Conclusion The expression of RhoA protein plays a role in the growth and invasion of human laryngeal carcinoma. It may be valuable as a predictor for growth, invasion and prognostic.
出处
《临床肿瘤学杂志》
CAS
2010年第7期646-648,共3页
Chinese Clinical Oncology
