摘要
目的研究对股骨头早期坏死有疗效的中药汤剂股骨头Ｉ号方药（以下简称Ｉ号药）的作用机理。方法用昆明小白鼠进行扭体试验、抗巴豆油致炎试验和游泳能力试验，检测Ｉ号药的镇痛、消炎和增强体能的效应。用醋酸氢化考地松造成家兔股骨头早期坏死的模型，分别用Ｉ号药、马氏骨丸和生理盐水进行１个月的治疗。为了评定Ｉ号药的疗效和机理，在造模前、造模后和治疗后，分别进行３次血清ＧＯＴ、ＴＧ和髋区的骨密度测定和病理组织学检查。结果和结论Ｉ号药有良好的镇痛、抗炎消肿和提高体能的效应；有降低ＧＯＴ、ＴＧ和提高骨密度的作用；Ｉ号药可以逆转激素诱发的股骨头骨质和骨髓早期的破坏、吸收和坏死等病理组织学变化，使其恢复近于正常股骨头的结构。
Objective To study the mechanism of therapeutic effect of Chinese traditional decoction,Femoral Head No.I (FHI) at the early stage of femoral head necrosis. Methods Kunming mice were applied to the body turning test,anti croton oil induced inflammation test,and swimming ability test,for examining the effectiveness of FHI on analgesia,anti inflammation,and enhancement of physical ability.Rabbits' models of femoral head necrosis at early stage induced with hydrocortisone acetate,were treated with FHI,Ma's Gu Wan,and normal saline for one month,respectively.In order to evaluate the therapeutic effect and its mechanism of FNI,before and after modeling and after treating,the content of serum GOT and TG,the bone density of hip region,and the pathohistology of femoral head were examined. Results and Conclusion There is good effect of FHI on analgesia,anti inflammation,repercussion,and elevation of physical ability.It plays a role in decreasing serum GOT and TG and in increasing bone density.FHI can reverse hydrocortisone induced pathohistological changes,such as the destruction,resorption and necrosis of bone mass and bone marrow at early stage of femoral head necrosis,thus recovering the structure of femoral head to approximately normal level.
出处
《中国骨伤》
CAS
1999年第1期17-20,共4页
China Journal of Orthopaedics and Traumatology
关键词
股骨头坏死
中医药治疗
病理学
Femoral head necrosis Treatment with Chinese drugs Pathology
