摘要
目的探讨应用中国韦氏成人智力量表(WAIS-CR)评价托吡酯与丙戊酸钠对癫痫患者认知功能的损害。方法 30例未经治疗的癫痫患者随机分为两组:托吡酯治疗组及丙戊酸钠治疗组(各15例)。所有患者在入组前及入组后3个月进行WAIS-CR问卷调查。结果托吡酯治疗组治疗前、后智力测定平均总IQ为(90.40±4.84)、(81.00±6.61)(P<0.05);丙戊酸钠治疗组治疗前、后智力测定平均总IQ分值为(88.33±4.70)、(87.40±5.34)(P>0.05)。结论托吡酯在用药早期影响癫痫患者的认知功能,使患者的总智商(FIQ)下降。
Objective To evaluate the cognitive impairment in epilepsy patients with Topiramate （TPM） or Valproate （VPA） treatment by using WAIS-CR. Methods30 untreated epilepsy patients were divided into two groups receiving TPM or VPA,respectively. All the patients were examined with WAIS-CR before and 3 months after treatment. ResultsThe IQ of TPM group decreased 3 months after treatment （P0.05）. ConclusionTPM may impair the cognitive function in epileptics reflected by decreased IQ.
出处
《中国康复理论与实践》
CSCD
2010年第7期648-649,共2页
Chinese Journal of Rehabilitation Theory and Practice
基金
北京市自然科学基金(7082041)
关键词
癫痫
托吡酯
丙戊酸钠
认知
韦氏成人智力量表
epilepsy
Topiramate
Valproate
cognition
Wechsler Adult Intelligence Scale
