摘要
目的：探讨抗生素联合治疗肝硬化原发性腹膜炎的临床治疗效果。方法：回顾分析本院2005年1月~2009年12月收治的肝硬化原发性腹膜炎患者162例,将其随机分为两组,治疗组（抗生素联合治疗）81例,对照组（单一抗生素治疗）81例进行对比治疗,分别观察其疗效。结果：治疗组显效63例,显效率为77.8%;有效11例,有效率为13.6%;无效5例,无效率为6.2%;死亡2例,病死率为2.4%;总有效率为91.4%。对照组显效34例,显效率为41.9%;有效29例,有效率为35.8%;无效13例,无效率为16.1%;死亡5例,病死率为6.2%;总有效率为77.7%。治疗组总有效率明显高于对照组（P〈0.05）。有89例出现不同程度的恶心、呕吐、视物模糊等症状,停药或减少剂量后症状减轻或消失;7例（治疗组2例,对照组5例）患者出现肝功能衰竭、肝性脑病死亡。结论：抗生素联合治疗肝硬化原发性腹膜炎,可有效提高疾病的治疗效果,延缓和避免耐药性的发生,值得在临床中推广应用。
Objective： To study the clinical effect of antibiotics in treatment of cirrhosis with primary peritonitis. Methods： Retrospective analyzed 162 patients with liver cirrhosis with primary peritonitis in hospital from January 2005 to December 2009. The patients were randomly divided into 2 groups, the treatment group （antibiotic combination therapy） 81 patients, the control group （antibiotic monotherapy） 81 patients,observed the effects. Results： The treatment group had 63 cases produced effects,the rate was 77.8%; 11 cases valid, the rate was 13.6%;5 cases in vain, the rate was 6.2%; 2 cases of death, the rate was 2.4%; the total effective rate was 91.4%. The control group had 34 cases produced effects, the rate was 41.9%; 29 cases valid, the rate was 35.8%; 13 cases in vain, the rate was 16.1%;5 cases of death, the rate was 6.2%; the total effective rate was 77.7%. 89 patients suffered from nausea, vomiting, blurred vision and other symptoms, discontinuation or reduction of symptoms relieved or disappeared after did, 7 patients （treatment group had 2 patients,control group had 5 patients） had liver failure, hepatic encephalopathy died. Conclusion： Antibiotics in the treatment of liver cirrhosis with primary peritonitis, which can effectively improve the treatment of disease, delay and prevent the occurrence of drug resistance, it is widely applied in clinical practice.
出处
《中国当代医药》
2010年第21期78-79,共2页
China Modern Medicine
关键词
抗生素联合治疗
肝硬化
原发性腹膜炎
Antibiotic combination therapy
Cirrhosis
Primary peritonitis
