摘要
目的：探讨ＨＬＡ与原因不明习惯性流产（ＲＳＡ）的关系。方法：用血清学方法对６４例３次以上ＲＳＡ患者及其配偶进行ＨＬＡ抗原检测，并与１００例正常群体比较。结果：ＨＬＡＡ、Ｂ、ＤＱ位点抗原频率在ＲＳＡ病人组与正常对照组中无明显差异，而ＨＬＡＤＲ７抗原频率在ＲＳＡ夫妇中则明显增高，为２１８８％（２８／１２８），Ｐ＜００１，ＲＲ值为２８。ＨＬＡＤＲ８在ＲＳＡ夫妇组中明显下降，为７０３％（９／１２８），Ｐ＜００１。结论：在上海人群中ＨＬＡＤＲ７可能与ＲＳＡ的易感有关。
Objective:To investigate the relation between recurrent spontaneous abortion(RSA)and HLA in Chinese Shanghai Han.Methods:Results of HLA typing by serology in 64 couples with at least 3 unexplained fetal loses were compared with those of 100 normal controls.Results:The distribution of HLA A, B,and DQ phenotypes did not differ significantly between patients and controls.The frequencies of DR7 was significantly increased in patients(21.88%,28/128),P<0.01,RR=2.8.The frequency of DR8 was significantly decreased in patients(7.03%,9/128),P<0.01.Conclusion:It is possible that the susceptibility of RSA for Chinese Shanghai Han were related with DR7.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1999年第3期135-137,共3页
Chinese Journal of Immunology
基金
卫生部及上海市自然科学基金
