摘要
目的从天然免疫角度探讨尖锐湿疣发病机制。方法收集尖锐湿疣患者45例及健康对照者25例,用实时荧光定量PCR技术检测外周血单个核细胞(PBMCs)TLR 2、3、9 mRNA的表达。结果尖锐湿疣组PBMCs TLR 2、3、9 mRNA表达水平与健康对照组比较,差异无统计学意义(P>0.05)。结论尖锐湿疣患者循环中的天然免疫受体TLR 2、3、9可能并未在抗尖锐湿疣病毒感染的免疫过程中起作用。
Objective To investigate the pathogenesis of Condylomata acuminata from the views of innate immune responses. Methods Forty-five cases of Condylomata acuminata patients and 25 cases of healthy controls were collected. Real-time quantitative PCR method was used to detect TLR 2,3,9 mRNA in the peripheral blood mononuclear cells（PBMCs）. Results The levels of TLR 2,3,9 mRNA had no significantly differences between patients and healthy controls. Conclusion It is suggested that systemic in- nate immunity may not play a role in the pathogenesis of condylomata acuminate.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第15期1968-1969,共2页
Chongqing medicine
关键词
尖锐湿疣
TOLL样受体
免疫
condylomata acuminata
toll-like receptor
immunity
