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维生素B_2片含量均匀度测定方法研究 被引量:3

Determination of Content Uniformity in Vitamin B_2 Tablets
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摘要 目的建立维生素B2片含量均匀度测定的质量标准。方法采用紫外-可见分光光度法测定维生素B2片的含量均匀度,溶媒:冰醋酸、4%氢氧化钠及水(按照5∶30∶965比例混合);样品处理:采用超声处理30 min;检测波长:444 nm;吸收系数(E11%cm):323。结果维生素B2在4~14μg/ml范围内与吸收度呈良好的线性关系,r=0.999 8,平均回收率为100.00%,RSD=0.86%(n=6)。结论所建立的方法简便准确,稳定性、重复性好,可作为维生素B2片的质量控制标准。 Objective To establish the quality standard for content uniformity in Vitamin B2 tablets.Methods It was used the UV-vis spectrophotometry to determinate the content uniformity in Vitamin B2 tablets.Solution was acetic acid glacial-4% sodium hydroxide-water(5∶30∶965);sample pretreatment: ultrasonic treatment for 30 minutes;detective wavelength: 444 nm;absorption coefficient(E1%1 cm): 323.Results There existed a good linear relation(r=0.999 8) between the Vitamin B2 content and the absorptance value within the range of 4~14 μg/ml.The average recovery was 100.0% with RSD 0.86%(n=6).Conclusion Accurate and repeatable results can be achieved by the simple determination method.The method is suitable for quality control standard of the Vitamin B2 tablets.
作者 陈振钦
出处 《今日药学》 CAS 2010年第7期13-15,共3页 Pharmacy Today
关键词 维生素B2片 含量均匀度 紫外-可见分光光度法 Vitamin B2 tablets content uniformity UV-vis spectrophotometry
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