摘要
目的:探讨磁共振波谱分析(MRS)在前列腺病变诊断中的价值。方法:对38例前列腺病变(前列腺癌15例,前列腺增生23例)的MRI和MRS进行研究。常规MRI评估前列腺病变的位置、形态、大小及信号特点;MRS观察枸橼酸盐(Cit)和胆碱复合物(Cho)、肌酸(Cre)的波峰及化学位移,并测定(Cho+Cre)/Cit值。结果:15例PCa在T2WI像上表现为外周带信号减低,其中9例为单侧局灶性,6例为双侧弥漫性;23例BPH在T2WI像上表现为前列腺移行带和中央带增大,其中14例为局灶性结节状高、低信号,9例为弥漫性体积增大,呈均匀低、等信号。MRS显示PCa的Cit峰明显下降,Cho峰升高,(Cho+Cre)/Cit值升高,而BPH病灶各代谢物波峰变化不明显,两者间(Cho+Cre)/Cit值有显著性差异(P<0.05)。结论:常规MRI平扫联合MRS有利于提高PCa和BPH的鉴别诊断率。
Objective： To assess the value of magnetic resonance spectroscopy （MRS） on diagnosis of prostate diseases. Methods： 38 patients with prostate diseases were researched by magnetic resonance imaging （MRI） and MRS, in which, 23 cases were benign prostatic hyperplasia（BPH） and 15 cases were prostate cancer （PCa） . Conventional MRI observation was focused on the size and configuration of the gland , the location of the lesion , the signal intensity of the tumor. MRS observation included the peak and the chemical shift of citrate（Cit） , choline （Cho） and creatine （Cre） spectra , and the ratio of （Cho＋Cre）/Cit . Results： In 15 cases of PCa , low T2WI signal intensity area in the peripheral zone was observed , 9 cases with localized mono side and 6 cases with both sides diffuse. In 23 cases of BPH, enlargement of the transitional and central zone of the grand was found on T2WI images, in which,14 cases presented as focal round high or low signal intensity nodular lesions , in the other 9 cases , the lesions were characterized by diffuse enlargement and well distributed low or isobaric signal intensity. On MRS, citrate peak was obviously declined and choline peak was ascended with the （Cho＋Cre）/Cit ratio being significantly risen in PCa （ P0.05, compared with which in BPH） . Conclusion： It is very helpful to discriminate BPH from PCa by using MRS and MRI.
出处
《中国医疗器械信息》
2010年第7期27-30,65,共5页
China Medical Device Information
关键词
前列腺癌
良性前列腺增生
磁共振成像
应用研究
磁共振波谱分析
prostate cancer
benign prostatic hyperplasia
magnetic resonance imaging
applied research
magnetic resonance spectroscopy
