摘要
目的探讨影响肝硬化下消化道出血（uGH）患者预后的相关因素。方法将315例肝硬化UGH患者分为好转组和死亡组，比较两组患者临床资料，并对有意义的单因素进一步行Logistic回归分析。结果单因素分析显示两组间UGH病史、胃镜检查结果、肝功能分级、休克指数、门静脉宽度、血清肌酐、凝血酶原时间、血红蛋白和血小板计数的差异有显著性（P〈0．05）；而年龄、性别、肝硬化原因、血清白蛋白、血清胆红素、是否合并脾切除、感染、肝性脑病、腹水的差异无显著性（P〉0．05）。Logistic回归分析表明：胃镜检查结果、休克指数、凝血酶原时间、血小板计数是影响肝硬化UGH预后的独立危险因素。结论胃镜检查结果、休克指数、凝血酶原时间、血小板计数可能是影响肝硬化UGH预后的独立高危因素，临床中对具有这些高危因素的患者应加以重视。
Objective To investigate the prognostic factors for upper gastrointestinal hemorrhage （UGH） in patients with liver cirrhosis. Methods A retrospective analysis of 315 cases of upper gastrointestinal hemorrhage in patients with liver cirrhosis was performed between January 2006 and December 2009 in The Cixi City People＇ s Hospital. All patients were divided into improved group and deteriorated group. The clinical data were analyzed using chi-square test and Binary logistic regression. Results Univariate analysis identified significant differences between the two groups with regard to UGH history, outcome of gastroscopy, liver function grade, shock index, pylephlebectasia, serum ereatinine, prothromtin time （PT）, total of blood haematoglobin and platelet. There were no statistical differences in age, gender, cause of cirrhosis, serum albumin, serum total bilirubin, splenectomy, infection, hepatic encephaeopathy, ascites between the two groups. On the logistic regression analysis, outcome of gastroscopy, shock index, prothromtin time （PT）, and total of blood platelet were selected as significant independent factors of prognosis. Conclusion Outcome of gastroseopy, shock index, prothromtin time （PT）, and total of blood platelet were selected as significant independent factors of prognosis, and may be useful to guide clinical treatment.
出处
《中国急救复苏与灾害医学杂志》
2010年第7期637-639,646,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
