摘要
目的观察β-七叶皂苷钠治疗特发性面神经麻痹的临床疗效。方法选择符合条件的特发性面神经麻痹患者20例,随机分为治疗组和对照组各10例。对照组给予糖皮质激素,治疗组给予七叶皂苷钠20mg,1次/d,两组均给予多种维生素、神经营养剂及对症治疗,共14d。采用Sunnybrook(多伦多)面神经功能评分标准,于治疗前和治疗后第14天对两组患者进行神经功能缺损评分。结果治疗14d后,治疗组分值由治疗前的(17.00±10.89)分上升到治疗后的(75.10±12.31)分;对照组分值由治疗前的(18.20±9.83)分改变为治疗后的(76.60±12.79)分;两组治疗后比较,治疗方法的主效应差异无统计学意义(P>0.05),治疗时间效应有统计学意义(P<0.05)。治疗组无明显不良反应。结论β-七叶皂苷钠治疗特发性面神经麻痹具有激素治疗相同疗效。
Objective To study the clinical therapeutic effects of sodium β-aescinate in the treatment of acute idiopathic facial palsy（AIFP）.Methods 20 patients with AIFP met with the diagnostic criteria was randomly assigned to trial group and control group（10 cases each group）.The trial group received sodium β-aescinate,and control group received prednisone.The basal treatment,including supply of various vitamins,acupuncture and moxibustion and physical therapy,was given to both groups.Scoring of nervous function defect in patients of both groups was carried out before the treatment and 14 days later by using Sunnybrook.Results In the trial group,the Sunnybrook scoring increased from（17.00±10.89）to（75.10±12.31）14 days after the treatment,while in the control group,the Sunnybrook scoring changed from（18.20±9.83）into（78.60±12.79）.Sunnybrook scoring before and after the treatment showed no obvious statistical difference in both groups（P0.05）,but the time of treatment had was significantly difference（P0.05）.No major adverse reactions were encountered in the trial group.Conclusion Sodium β-aescinate has the same effect to prednisone in treating AIFP.
出处
《中华全科医学》
2010年第8期956-957,共2页
Chinese Journal of General Practice
