摘要
目的:观察慢性阻塞性肺疾病急性加重期(AECOPD)患者采用谷氨酰胺(Gln)、左卡尼汀和1,6-二磷酸果糖强化肠外营养治疗的临床疗效。方法:将63例AECOPD患者随机分为强化组(33例)和常规肠外组(30例),2组经14d营养治疗后,比较2组治疗前后氧分压(PaO2)、二氧化碳分压(PaCO2)、体质量指数、白蛋白、淋巴细胞计数、能脱离呼吸机者数和脱离呼吸机者使用呼吸机天数、控制感染的时间。结果:强化组脱离呼吸机者例数与常规肠外组比较无显著性差异(P>0.05),但在改善AECOPD患者的PaO2和PaCO2及缩短脱离呼吸机者使用呼吸机天数等方面均优于常规肠外组,同时在改善AECOPD患者营养状况方面亦优于常规肠外组,2组比较有显著性差异(P<0.05)。结论:通过Gln、左卡尼汀和1,6-二磷酸果糖强化肠外营养支持,能够改善AECOPD患者的PaO2、PaCO2和营养状况,缩短使用呼吸机时间和感染控制时间。
OBJECTIVE：To observe clinical efficacy of acute exacerbations of chronic obstructive pulmonary disease （AECOPD） treated with intensified TPN by adopting glutamine,levocarnitine and 1,6-fructose diphosphate.METHODS：63 patients with AECOPD were divided into intensified group （33 cases） and routine group （30 cases）.After 14 days of treatment,PaO2,PaCO2,Body mass index,albumin count,lymphocyte count,amount of patients without respirator,the number of application days in patients without respirator,time of infection control of 2 groups were compared before and after treatment.RESULTS：Although there was no significant difference in amount of patients without respirator between 2 groups （P0.05）,PaO2,PaCO2 of patient and to shorten the number of application days in intensified group were better than in routine group.The improvement of nutritional status in intensified group was also superior to routine group.There was significant difference between 2 groups （P0.05）.CONCLUSION：Glutamine,levocarnitine and 1,6-fructose diphosphate are adopted to intensify TPN,which can improve PaO2,PaCO2,nutritional status in AECOPD patient＇s,shorten application days of respirator repand is infected with and the time of infection control.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第28期2612-2614,共3页
China Pharmacy
基金
广西卫生厅立项课题(Z2008466)
