摘要
目的观察应用减阻剂(drag-reducing polymers,DRPs)后大鼠腹主动脉血流量的变化,同时评价DRPs对实验鼠心率、血压的影响,为进一步开展减阻剂医学应用研究奠定方法学基础。方法 200～250g的Wistar大鼠16只随机分为两组(对照组、实验组)。2%戊巴比妥钠腹腔麻醉后分离大鼠的腹主动脉,安置多普勒流量仪探头,用于监测腹主动脉血流量;颈动脉插管监测血压;同时进行心电监测。对照组经颈静脉按照5mL/h的速度注入0.9%氯化钠溶液,实验组以相同的速度注入1×10-5g/mL的聚氧化乙烯(polyethylene oxide,PEO)溶液,连续给药30min。自给药开始至停药后30min,连续监测主动脉血流量、心率、血压。结果实验组在注射低浓度的PEO后主动脉血流较基础状态明显增加[(6.2±2.5)mL/s vs.(4.9±1.7)mL/s,P=0.008];对照组在给药前、后主动脉血流量比较,差异无统计学意义[(4.9±1.1)mL/s vs.(5.0±1.4)mL/s,P=0.589]。实验组及对照组在给药前后心率、血压比较,差异无统计学意义(P>0.05)。结论 DRPs在低浓度条件下可以增加实验鼠腹主动脉血流量,且不影响心率和血压。
Objectives To observe the effects of drag-reducing polymers：polyethylene oxide （ PEO ） on the abdominal aortic blood flow.The safety of PEO on rats was evaluated by monitoring blood pressure and heart rate during and after PEO injection.Methods Sixteen male Wistar rats were randomly divided into two groups： experimental group and control group.Catheters was placed in the carotid artery for measuring blood pressure.An ultrasonic flow probe was placed around the abdominal aorta.1×10^-5 g / mL PEO was injected into the jugular vein at the speed of 5 mL / h for 30 minutes in experimental group,while normal saline was injected in control group at the same speed for 30 minutes.Heart rate,blood pressure,and flow were continuously monitored during PEO or normal saline injection and 30 minutes after injection.Results Abdominal aortic blood flow was increased significantly after PEO injection than baseline [（6.2±2.5） mL / s vs.（4.9±1.7）mL / s,P=0.008],and the abdominal flow was similar before and after normal saline injection [（4.9± 1.1）mL / s vs.（5.0±1.4）mL / s,P=0.589].Both PEO and normal saline had no influence on the heart rates and blood pressures （P〉0.05）.Conclusions Purified PEO increases blood flow at very low concentration while no influence on the heart rate and blood pressure.
出处
《岭南心血管病杂志》
2010年第2期140-142,共3页
South China Journal of Cardiovascular Diseases
关键词
腹主动脉
减阻剂
聚氧化乙烯
血流量
血压
心率
abdominal artery
drag-reducing polymers
polyethylene oxide
blood flow
blood pressure
heart rate
