摘要
目的通过对健康人群流行性乙型脑炎(乙脑)病毒中和抗体水平检测,评价人群乙脑免疫屏障,分析影响人群抗体水平的因素,为制定乙脑预防控制策略提供依据。方法根据既往乙脑发病率选取高、中、低三个地区,在每个地区采取整群随机抽样,抽取7个年龄组756名健康人,用微量中和试验检测乙脑病毒中和抗体。结果乙脑发病高、中、低三个地区(安康、宝鸡、铜川)乙脑病毒中和抗体阳性率(几何平均滴度)分别为:81.3%(1︰27.84)、47.9%(1︰7.41)、24.1%(1︰3.04);在乙脑高流行地区随着年龄的增加抗体水平呈现明显的增长趋势,但在低流行区无此趋势。结论陕西省乙脑高发病率地区小年龄组人群抗体水平低,应重点加强小年龄组儿童乙脑疫苗的接种;低发病率地区成人抗体水平较低,在加强儿童乙脑疫苗接种的同时,应关注成人乙脑的预防控制。
Objective To detect Japanese B Encephalitis virus（JEV） neutralization antibody（NA） titer and evaluate immunologic barrier,analyze the factor of affecting JEV NA titer,and provide the data for JE control.MethodCluster sampling was selected randomly in the region of high,middle,low JE incidence rate.To detect the NA of JEV by micro neutralization test.ResultsThe positive rate of JEV NA（and GMT） was 81.3%（1︰27.84） in Ankang prefecture where JE incidence rate was high,47.9%（1︰7.41） in Baoji prefecture where JE incidence rate was middle,24.1%（1︰3.04） in Tongchuan prefecture where JE disease rate was low.There was the tendency that JEV NA titer increased with increasing age in the region of high JE disease rate,and there was not this tendency in the region of low JE incidence rate.ConclusionIn shaanxi province,the children＇s JEV NA titer was low in the region of high JE incidence rate,and it is important to vaccinate JE vaccine for children.The adult＇s JEV NA titer was low in the region of low JE incidence rate.And it is important to control JE disease in adult groups.
出处
《中国疫苗和免疫》
CAS
2010年第3期251-253,257,共4页
Chinese Journal of Vaccines and Immunization
基金
陕西省卫生厅科学研究基金项目(编号08D13)
关键词
流行性乙型脑炎
中和抗体
健康人群
Japanese B encephalitis
Neutralization antibody
Health people
