摘要
【目的】比较异丙酚和哌氟合剂辅助硬膜外麻醉的镇静、抗牵拉反应效果、对循环呼吸的影响，以及术后恶心呕吐发生率。【方法】腹部手术患者４０例随机分成哌氟组（２０例）和异丙酚组（２０例），在连续硬膜外麻醉下，哌氟组予哌替啶１ｍｇ／ｋｇ，氟哌啶０．０５ｍｇ／ｋｇ单次静脉注射，异丙酚组先予异丙酚０．５ｍｇ／ｋｇ静注，继以２ｍｇ／（ｋｇ·ｈ）静滴持续至手术结束。【结果】异丙酚比哌氟合剂的镇静效果更好，差异有显著性（Ｐ＜０．０５）。两者对呼吸无明显影响，异丙酚组在术中探查时有血压下降，该剂量异丙酚也不能有效地拮抗牵拉反应。【结论】异丙酚可作为腹部手术连续硬膜外麻醉的辅助用药，但应注意循环变化，及时补充血容量；其拮抗牵拉反应有待进一步探索。
Objective The Therapeutic efficiencies of propofol and pethidine-droperidol were compared in four aspects,including their sedative effects for epidural block,efficacy of antitraction response,effects on circulation-repiratory system and the occurrence rate of nausea and vomiting after operation. Methods Forty patients for abdominal operation were divided randomly into 2 groups:①under continuous epidural block,20 patients received a loading dose of 0.5 mg/kg propofol intravenously and were followed by fixed-rate infusion of 2 mg/(kg·h) propofol till the operation finished;②the other 20 patients received one single dose of 1mg/kg pethidine and 0.05 mg/kg droperidol iv. Results The given dosage of propofol provided more satisfactory sedation than pethidine-droperidol did( P <0.05),but propofol could not effectively reduce traction response.During abdominal exploration,mean arterial pressure (MAP) decreased significantly in patients treated with propofol.Neither the given dosage of propofol nor pethidine-droperidol caused significantly respiratory depression. Conclusions Propofol infusion is an effective sedative for abdominal operation during continuous epidural block.But we should pay careful attention to the circulatory changes and supplement the blood volume on time.
出处
《湖南医学》
1999年第1期1-3,共3页
Hunan Medical Journal
