摘要
目的：研究黄芩苷在家兔获得脑水肿前后，体内药代动力学参数的变化。方法：１８只家兔随机分为两组，一组感染百日咳菌液获得脑水肿模型，另一组为正常对照组，静脉注射６０ｍｇ／ｋｇ黄芩甙，于注射后不同时间内抽取血样，采用高效液相色谱法测定，黄芩甙血药浓度测定值用３Ｐ８７程序包进行拟合。结果：静脉注射黄芩甙后，在家兔体内代谢符合二室开放模型。对照组与脑水肿模型组的主要药动力学参数：ｔ１／２α分别为０１１９６ｈ和０２１５８ｈ；ｔ１／２β分别为２３８１ｈ和２５６２ｈ；Ｖｄ分别为１００６Ｌ·ｋｇ－１和１４１４Ｌ·ｋｇ－１；ＣＬ分别为１８４３Ｌ·ｈ－１·ｋｇ－１和１８７７Ｌ·ｈ－１·ｋｇ－１。结论：用黄芩苷治疗脑水肿时。
OBJECTIVE:To study the varity of pharmacokinetic parameters of baicalin in normal rabbits and in rabbits with inflammatory brain edema and to evaluate its clinical use for the treatment of brain edema.METHOD:18 rabbits were randomizedly divided into two groups PB brain edema group and control.After injecting 60 mg·kg -1 baicalin,serum samples were collected at 0,0 25,0 5,1,2,4,6,8h.A high performance liquid chromatography method was used to determine the serum concentrations. The data obtained were fitted with 3P87 pharmacokinetic program.RESULTS:The result showed that the disposition of baicalin in rabbits was conformed to a two compartment model.The main pharmacokinetic parameters of control group and brain edema group were t 1/2α 0 1196h and 0 2158h, t 1/2β 2 381h and 2 562 h, V d 1 006L·kg -1 and 1 414L·kg -1 , CL 1 843 L·h -1 ·kg -1 and1 877L·h -1 ·kg -1 ,respectively. CONCLUSION:The pharmacokinetic parameters of baicaclin in rabbits with brain edema were different from control group. It has longer t 1/2α and higher apparent volume of distribution.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
1999年第2期107-109,共3页
Chinese Pharmaceutical Journal
