摘要
同时应用环胞菌素A(CSA),抗胸腺细胞球蛋白(ATG),大剂量免疫球蛋白(HDIG)和大剂量甲基泼尼松龙(HDMP)等免疫抑制剂对17例小儿SAA(10例SAA-Ⅰ,7例SAA-Ⅱ)进行联合免疫抑制(IS)治疗。结果:3例基本治愈,7例缓解,3例明显进步,总有效率达76.5％(13/17例)。其中10例SAA-Ⅰ的总有效率为80％。在总共13例有效病例中,大部分(10/13例,76.9％)为缓解或基本治愈,故有效率及显效质量均明显高于近年来单药治疗SAA的报道,联合IS治疗期间未见明显感染倾向加重或脏器功能损害。
Combined immunosuppressive (IS) therapy were undertaken in 17 cases of childhood severe aplastic anemia (SAA)(10 cases SAA-I and 7 cases SAA-IDwith cyclosporin A(CSA), antithymocyte globulin (ATG). high-dose im-munoglobulin (HDIG) and high-dose methylprednisolone (HDMP). The results showed that there was a response rate o{ 76- 5%(13/17) including cure on 3 cases, complete response on 7 cases (CR)and partial response (PR) on 3 cases, respectively. Eight of 10 cases (80%) with acute SAA (SAA-I) were well response to the combined therapy. It is confirmed that the response rate and response grade in the patients treated by multiple IS agents were significantly higher than that by single IS agents reported previously. No severe side-effects were observed during combined IS therapy.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
1999年第1期36-39,共4页
Journal of Clinical Pediatrics
关键词
再生障碍性贫血
儿童
免疫抑制剂
联合疗法
aplastic anemia Cyclosporin A antithymocyte globulin high-dose immunoglobulin
