摘要
目的 评价老年急性冠脉综合征（ACS）患者入院时估算的肾小球滤过率（eGFR）与冠脉病变程度和血浆高敏C-反应蛋白（hs-CRP）的相关性.方法 选择284例老年ACS患者,在入院后12 h内行血肌酐等常规检查,同时检测血浆hs-CRP.结果 肾功能不全的比率为55.30%,肾功能不全总组及肾功能不全轻、中、重组Gensini评分均较正常肾功能组显著增高（P〈0.01,P=0.01,P〈0.01,P〈0.001）.肾功能不全总组及重度肾功能不全组血浆hs-CRP显著增高（P=0.02,P〈0.01）.与Gensini评分〈30组相比较,高hs-CRP和肾功能不全比率Gensini评分30～90组和Gensini评分〉90组均显著增高（P〈0.01,P〈0.01）.偏相关分析表明,eGFR及血浆hs-CRP分别与Gensini评分相关（r=-0.110,P=0.005;r=0.045,P=0.01）.多元回归分析表明,eGFR及血浆hs-CRP分别与Gensini评分独立相关（β=-0.113,P〈0.01;β=0.035,P〈0.01）.血浆hs-CRP与eGFR无相关性.结论 老年ACS患者eGFR水平与冠脉病变程度独立相关,与血浆hs-CRP结合可能更有利于老年ACS患者的临床评价.
Objective To explore the correlation of the estimated glomerular filtration rate （eGFR）, the severity of coronary artery stenosis and plasma Hs-C reactive protein（hs-CRP） in elderly patients with acute coronary syndromes（ACS）. Methods Serum creatinine and hs-CRP within 12 hours were analyzed in 284 elderly patients with acute coronary syndromes. Results Incidence of renal disfunction was 55.30%, Gensini score in these patients were higher than those with normal renal function （P〈0.01）. The percentages of high hs-CRP and renal disfunction were significantly higher in patients with Gensini score 30-90 and patients with Gensini score〉90 compared patients with Gensini score 〈30 （P〈0.01 ,P〈0.01 ）. Partial correlation analysis showed Gensini score correlated with eGFR and plasma hs-CRP （r=-0.110,P=0.005,r=0.045,P=0.01）. Mutiple linear regression analysis showed both eGFR and plasma hs-CRP correlated independently with Gensini score（fl=-0.113,P〈0.01 ,fl=0.035, P〈0.01 ） while plasma hs-CRP was not correlated with eGFR. Conclusion eGFR independently correlated with Gensini score in elderly patients with acute coronary syndromes and the conrbined measurement of plasma hs-CRP are helpful in evaluating the prognosis of elderly patients with acute coronary syndromes.
出处
《中国心血管病研究》
CAS
2010年第7期500-502,共3页
Chinese Journal of Cardiovascular Research
关键词
肾小球滤过率
C-反应蛋白
急性冠脉综合征
Glomerular filtration rate
C-reactive protein
Acute coronary syndromes
