摘要
目的调查湖北地区2003-2007年大肠埃希菌的耐药性变迁,为临床医师抗感染化疗提供试验依据。方法采用WHONET4.0～5.0软件,对湖北省细菌耐药监测协作组17所三级医院5年患者临床标本中分离的12 286株大肠埃希菌的耐药监测资料进行统计分析。结果近5年中,湖北地区大肠埃希菌对常用抗菌药物的耐药率大部分呈上升趋势,其中对头孢类的耐药率上升幅度较大;对氨苄西林耐药率高达88.0%～93.0%;对碳青酶烯类抗菌药物亚胺培南和美罗培南100.0%敏感;产超广谱β-内酰胺酶菌株的检出率由30.2%上升到54.8%,呈逐年上升趋势。结论湖北地区大肠埃希菌的耐药现状十分严重,应加强细菌耐药性的监测与控制,遏制多药耐药菌的产生与流行。
OBJECTIVETo investigate antibiotic resistance changing of Escherichia coli（ECO） in Hubei region during from 2003 to 2007 and provide the evidence for clinical application of antibiotics.METHODS The WHONET 4.0-5.0 software was used to analyze the antibiotic resistance of 12286 ECO strains isolated from clinical specimens of adult patients in 17 tertiary care hospitals by the Hubei monitoring and Cooperation Group on Antibiotic Resistance during the last five years.RESULTS The resistance rates of ECO to commonly used antibiotics were on the rise mostly in Hubei.The drug resistance rate to cephalosporins rose to comparatively large extent.The resistance rate to ampicillin was 88-93%.100% of ECO isolates were susceptible to carbapenems such as imipenem and meropenem.The detection rate of extensive-spectrum beta-lactamase（ESBLs） producers in ECO increased from 30.2% to 54.8% gradually.CONCLUSIONThe antibiotic resistance status in ECO is very serious in Hubei Province.We should intensify the monitoring and controlling of antibiotic resistance so as to prevent the multidrug-resistant strains from occurring and prevailing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第13期1927-1928,共2页
Chinese Journal of Nosocomiology
基金
湖北省自然科学基金资助项目(2004ABA153)
关键词
湖北省细菌耐药监测协作组
三级医院
大肠埃希菌
耐药性
变迁
Hubei Monitoring and Cooperation Group on Antibiotic Resistance
The tertiary care hospital
Escherichia coli
Drug resistance
Changing
