摘要
沙眼衣原体(CT)是最常见的性传播疾病的病原体之一。患者感染后常因无症状而未能及时接受治疗。持续性CT感染可引起输卵管损害,导致输卵管性不孕等严重后果。清除病原体的关键在于机体正常的免疫应答。Toll样受体(TLR)家族和核苷酸结合的寡聚结构域(NOD)家族是固有免疫系统的关键模式识别受体(PRRs),在CT感染识别和启动免疫应答中发挥重要作用。近年较多证据关注到CT感染后输卵管性不孕的遗传学特征,并发现部分PPRs、人类白细胞抗原和细胞因子的基因多态性与CT易感性和输卵管感染后结局相关。
Chlamydia（C.）trachomatis is the most prevalent sexually transmitted diseases.Due to the mostly asymptomatic course of infection,these women will most likely not be treated and have persistent C.trachomatis infections,which may increase the risk of tubal pathology and tubal factor infertility.Therefore,an adequate immune response is essential to clear the pathogen.Pattern recognition receptors（PRRs）of the toll-like receptor（TLR）and nucleotide-binding oligomerization domain（NOD）families play a substantial role in recognizing C.trachomatis and initiating the immune response.Recent studies have shown the value of genetic trait in C.trachomatis-associated tubal factor infertility.Genetic variations in some PPRs and human leukocyte antigen and cytokine genes tend to increase the susceptibility,course and outcome of C.trachomatis infections.
出处
《国际生殖健康／计划生育杂志》
CAS
2010年第4期298-301,共4页
Journal of International Reproductive Health/Family Planning
关键词
衣原体
沙眼
TOLL样受体
多态性
限制性片段长度
不育
女(雌)性
输卵管
NOD蛋白
关键模式识别受体
Chlamydia trachomatis
Toll-like receptors
Polymorphism
restriction fragment length
Infertility
female
Fallopian tubes
Nucleotide-binding oligomerization domain
Pattern recognition receptors
