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PI_3K/Akt与血液恶性肿瘤关系的研究进展 被引量:4

Advance in the Relationship between PI_3K/Akt and Blood Malignancy
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摘要 在肿瘤的发生发展中,细胞的凋亡受抑在细胞生存中起着主要的作用。磷酸肌醇3激酶/蛋白激酶B(PI3K/Akt)信号通路与肿瘤发生发展中的许多细胞生物学过程存在着密切联系,这些生物学过程包括:细胞凋亡、转录及细胞周期的调控等。因此,探讨PI3K/Akt作用的分子机制并揭示其与肿瘤的关系将为抗肿瘤药物的研究提供新靶点。 In the development of tumor,the suppression of apoptosis plays an important role in the survival of tumor cells.There is a close link between PI3k/Akt signal pathway and many biological processes in the development of tumor.These biological processes include apoptosis,transcription and cell cycle control.Therefore,the exploration of the molecular mechanisms of PI3K and the relationship with tumor can provide new drug targets.
作者 黄青 王少元
出处 《医学综述》 2010年第14期2135-2137,共3页 Medical Recapitulate
基金 福建省重大科技项目(2003F003) 福建省科技创新平台建设福建省血液病学重点实验室(2009J1004)
关键词 磷脂酰肌醇3激酶 蛋白激酶B 肿瘤 PI3K Akt Tumor
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参考文献18

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