摘要
双组分系统(Two-component systems,2CS)是高度保守的原核信号转导系统,最简单的2CS由感受器-组氨酸激酶(Histidine Kinase,HK)和效应器-反应调节器(Response Regulator,RR)组成。PhoPR是结核分枝杆菌中最重要的双组分系统,PhoP是结核分枝杆菌PhoPR2CS中的反应调节器。运用转录组学和蛋白组学分析可以揭示PhoP基因调控结核分枝杆菌的许多功能。本文对双组分系统PhoPR及PhoP基因在结核分枝杆菌中的研究进展进行了综述。
Two-component systems（2CS） are highly conserved prokaryotic signal transduction pathways.The simplest 2CS consists of a sensor histidine kinase（HK） and an effector response regulator（RR）.PhoPR is the most important two-component system in Mycobacterium tuberculosis while PhoP is the response regulator in the PhoPR 2CS of M.tuberculosis.Transcriptomic and proteomic analysis studies showed that PhoP controls a variety of functions of M.tuberculosis.This review is based on studies of the PhoPR 2CS and PhoP gene of M.tuberculosis.
出处
《中国病原生物学杂志》
CSCD
2010年第6期458-461,共4页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.30960356)
