摘要
目的综述组织工程全层皮肤的研究进展,全面了解其研究现状及应用情况,为研制新型组织工程全层皮肤、改善皮肤替代物的性能奠定基础。方法广泛查阅近年来国内外组织工程全层皮肤的相关文献,并进行综合分析。结果组织工程全层皮肤在种子细胞、支架材料及构建方面均取得了一定进展,在临床应用中已经取得了一定的疗效,但移植成功率低,也不具备完整的皮肤结构,还不能完全达到临床应用的要求。结论组织工程全层皮肤是理想的皮肤替代物,发展前景很大,但在种子细胞、支架材料及构建应用等方面仍需进一步研究。
Objective To review the latest research progress of full-thickness tissue engineered skin（FTTES）,to thoroughly understand its current state of research and application so as to lay a solid foundation for developing new type FTTES and improving the quality of skin substitutes.Methods Domestical and international literature concerning FTTES in recent years was extensively reviewed and comprehensively analyzed.Results Some progress of FTTES had made in seed cells,scaffold materials and construction,and some therapeutic efficacy had also been achieved in clinical application.But FTTES grafting successful rate was lower,and it had no complete skin structure and had not reached the requirements of clinical application.Conclusion FTTES is an ideal skin substitute and has great development prospects.However,in seed cells,scaffold materials,construction and applications of FTTES,further studied is still needed.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第7期854-859,共6页
Chinese Journal of Reparative and Reconstructive Surgery
基金
卫生公益性行业科研专项项目(200802066)
第45批中国博士后科学基金(20090451510)~~
关键词
组织工程全层皮肤
干细胞
创面修复
Full-thickness tissue engineered skin Stem cells Wound repair
