摘要
目的总结功能性组织工程肌腱(functional tissue engineered tendons,FTETs)的研究和应用。方法查阅近年来国内外有关FTETs研究的相关文献,并进行综合分析。结果功能性组织工程(functional tissue engineering,FTE)作为一种新方法 ,强调了机械应力对于成功构建组织工程复合物的重要性以及对体内组织重塑的影响。在组织工程肌腱的研究中引入FTE方法 ,通过测量正常肌腱组织的体内载荷,利用这些信息指导设计能承受体内载荷的合适的组织工程肌腱复合物,可望解决修复肌腱缺损的组织工程肌腱生物力学功能不能满足体内力学环境需要的问题。结论 FTETs对于治疗肌腱缺损具有广阔的应用前景。
Objective To review the research and application of functional tissue engineered tendons（FTETs）.Methods Recent literature concerning the research of FTETs was reviewed and analyzed.Results Functional tissue engineering（FTE） was a new approach that placed an emphasis on the importance of mechanical stress in determining the success of tissue engineered constructs and the effect of tissue remodeling in vivo.The concept of FTE was introduecd into the research of tissue engineered tendons;by measuring in vivo loads of normal tendon and using the information as a guideline,the appropriate tissue engineered tendon which can withstand in vivo loads was designed.It would be possible to solve the problems that the biomechanical function of the tissue engineered tendons could not meet the requirements of the loading environment in vivo.Conclusion FTETs have a more promising future for the treatment of tendon defects.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第7期850-853,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(30570469)
教育部留学回国人员科研启动基金资助项目[(2010)609]~~
关键词
功能性组织工程肌腱
生物力学功能
力学刺激
Functional tissue engineered tendon Biomechanical function Mechanical stimulation
