摘要
目的:观察益气活血方对异丙肾上腺素致大鼠心肌肥大不同病理阶段的影响。方法:以异丙肾上腺素20、10、5mg/kg递减皮下注射,3mg/kg维持7d制备大鼠心肌肥大模型,给予益气活血方5、10、15w,观察大鼠血流动力学指标、心输出量、心脏指数、左心室指数以及血清心房利钠肽(ANP)、脑钠肽(BNP)含量的变化。结果:与模型组比较,益气活血方在5、10、15w3个时间点均能显著增加心输出量,提高心肌收缩功能,改善心肌舒张功能(P<0.05)并能有效降低ANP、BNP含量(P<0.05),降低大鼠心脏指数与左心室指数(P<0.05)。结论:益气活血方能有效改善大鼠血流动力学,增加心输出量,降低神经体液因子水平。
Objective：To observe the effect of Qi-Benefiting,Blood-Activating Recipe on the different pathologic stage of myocardial hypertrophy induced by ISO in rats.Methods：Myocardial hypertrophy rats were induced by isoproterenol,and treated with Qi-Benefiting,Blood-Activating Recipe for 5,10 and 15 weeks,hemodynamic parameters,LVMI,HMI were determined,ANP and BNP were analysed.Results：Qi-Benefiting,Blood-Activating Recipe could increase cardiac output and improve hemodynamic parameters all after 5,10 and 15 weeks＇ treatment（P0.05）.It could decrease the contents of ANP and BNP after 5,10 and 15 weeks＇ treatment（P0.05）.Qi-Benefiting,Blood-Activating Recipe could significantly decrease the levels of HWI and LVMI after 5,10 and 15 weeks＇ treatment（P0.05）.Conclusion：Qi-Benefiting,Blood-Activating Recipe can significant improve hemodynamic status,increase cardiac output and decrease the level of neurohormoal factors.
出处
《中药材》
CAS
CSCD
北大核心
2010年第5期749-753,共5页
Journal of Chinese Medicinal Materials
基金
国家自然基金项目(30973821)
上海市教委基金资助项目(07CZ03)
上海市教育委员会重点学科建设项目资助(J50301)
上海高校中医内科学E-研究院项目(E03008)
上海市重点学科建设项目(S30301)
关键词
益气活血方
心肌肥大
异丙肾上腺素
Qi-Benefiting
Blood-Activating Recipe
Myocardial hypertrophy
Isoproterenol
