摘要
目的:研究适合我国缺血性脑血管病抗凝监测的国际规格化比值(InternationalNormalizedRatio简称INR)范围。方法:对14例抗凝治疗患者,同时监测凝血酶原时间(PT)及其活动度(AT)、INR,并将结果进行对照分析。结果:所有患者均达到了预期的治疗效果,抗凝期间出血发生率为14.3%,无1例发生严重或致命性出血。359次检测中AT值位于25%~44%者占75.5%,此时相应的INR值为1.88~3.20。结论:采用INR监测抗凝治疗时建议治疗范围控制于2.0~3.0。
Purpose:To study the proper range of international normalized Ratio (INR) for oral anticoagulant therapy in patients with ischemic cerebrovascular disease.Method:Fourteen patients with ischemic cerebrovascular disease who received anticoagulant therapy,prothrombin time (PT),activity of prothrombin (AT) and INR were monitored and compared.Results:All patients had optimal outcome.The percentage of bleeding during oral anticoagulant was 14.3%.None of these patients had serious or fatal bleeding.Among the total 359 AT tests,271(75.5%) AT tests ranged between 25% to 44%,the corresponding INR were between 1.88 to 3.20.Conclusion:This study suggested that INR between 2.0 to 3.0 might be a proper range for anticoagulant therapy in Chinese patients with ischemic cerebrovascular diseases.
出处
《卒中与神经疾病》
1999年第1期31-33,共3页
Stroke and Nervous Diseases
关键词
抗凝监测
治疗
国际规格化比值
缺血性脑血管病
Oral coagulantion International normalized ratio Ischemic vascular disease