摘要
通过硫代水杨酸与(1-氯甲基)-1,2,4-三唑盐酸盐在碱性条件下的反应,合成了2-[(1,2,4-三唑-1-基)甲基硫代]苯甲酸.利用该酸与(R3Sn)2O(R=Et,n-Bu,Ph),Cy3SnOH(Cy为环己基)或Et2SnO反应,得到了5个有机锡羧酸酯.用X射线单晶衍射测定了三正丁基锡2-[(1,2,4-三唑-1-基)甲基硫代]苯甲酸酯的晶体结构.在该化合物中,锡为五配位的三角双锥结构.该化合物通过三唑四位氮原子与锡配位,形成一维链状配位高分子.初步的生物活性测试结果表明,所有的有机锡化合物都表现出了明显的抗真菌活性.
Triazole and its derivatives have attracted broad attention owing to their good coordination ability as well as extensive biological activities.In this paper,a new carboxylic acid with triazole moiety,namely 2-[（1,2,4-triazol-1-yl）methylthio]benzoic acid,was synthesized by the reaction of thiosalicylic acid with 1-chloromethyl-1,2,4-triazole-HCl.Five organotin 2-[（1,2,4-triazol-1-yl）methylthio]benzoates were obtained upon treatment this acid with（R3Sn）2O（R=Et,n-Bu,Ph）,Cy3SnOH（Cy=cyclohexyl） and Et2SnO.The molecular structure of tri（n-butyl）tin 2-[（1,2,4-triazol-1-yl）methylthio]benzoate determined by X-ray crystallography showed that the tin atom was a five-coordinate distorted trigonal bipyramidal geometry with the exodentate nitrogen atom on 4-position of triazole ring and carboxyl oxygen atom occupying the apical position.Moreover,this complex formed a linkage coordination polymer through the intermolecular Sn…N interactions.All these complexes displayed good antifungal activities in vitro against Alternaria solani,Cercospora arachidicola,Gibberella zeae,Physalospora piricola and Botrytis cinerea.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第6期1162-1166,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20721062)资助
关键词
有机锡羧酸酯
1
2
4-三唑
晶体结构
抗真菌活性
Organotin carboxylate
1
2
4-Triazole
Crystal structure
Antifungal activity
