摘要
目的：研究抑癌基因Ｐ１６在脑胶质瘤发生过程中的作用及作用机理；方法：应用Ｓ—Ｐ免疫组化方法对５２例病人脑胶质细胞瘤中抑癌基因Ｐ１６的表达进行了研究；结果：５２例胶质瘤中Ｐ１６蛋白阳性率为５３．８％（２８／５２），其中Ⅰ级胶质瘤的阳性率高，为９０％（９／１０），依次为Ⅱ级７１．４％（１０／１４），Ⅳ级３７．５％（３／８），Ⅲ级最低为３０％（６／２０）；结论：抑癌基因Ｐ１６的表达在胶质瘤的病理分级与恶性程度等方面有显著差异性，提示Ｐ１６抑癌基因在胶质瘤的发生，发展过程中起重要作用。
Objective:To investigate the mechanism of suppress tumor gene P16 of transformation in brain gliomas.Method:All the cases of astrocytoma were detected by immunohistochemistry,being used corresponding monoclonal antibodies with streptavidin peroxdase conjugated method (sp method).Result:The ratio of P16 positive cases to all the cases was 53.8(28/52).Among these cases,the ratio of P16 protein positive to negative cases in grade me samples was 90%(9/10),grade two samples wsa,mpl;es was 71.4%(10/14),grade IV samples was 37.5%(3/8),and the smallest ratio of P16 protein positive in grade Ⅲ sapmples was 30%(6/20).There is a significant difference between P16 expression and gliomas grade as well as malignant grade.Conclusion:It is indicated that P16 gene might play an important role in the development and transformation of brain gliomas.
出处
《河北医学》
CAS
1999年第1期5-7,共3页
Hebei Medicine
