摘要
目的探讨丹参酮ⅡA磺酸钠对早期糖尿病肾病(DN)患者血清转化生长因子β1(TGF-β1)和Ⅳ型胶原(CⅣ)水平的影响。方法 64例早期DN患者随机分为两组,对照组(32例)采用糖尿病常规治疗,治疗组(32例)在常规治疗基础上加用丹参酮ⅡA磺酸钠,疗程均为1个月。采用ELISA法测定两组患者治疗前后血清TGF-β1、CⅣ水平,同时观察尿白蛋白排泄率(UAER)的变化。结果治疗组患者治疗后血清TGF-β1、CⅣ水平明显下降(P<0.01);对照组血清TGF-β1、CⅣ水平治疗前后比较无明显变化(P>0.05)。两组治疗后UAER均较治疗前降低,治疗组降低更明显(P<0.01)。结论丹参酮ⅡA磺酸钠可降低早期DN患者的血清TGF-β1、CⅣ水平,延缓DN的发展。
Objective To investigate the effect of sulfotanshinone sodium injection on transforming growth factor-beta 1 （ TGF -β1 ） and type Ⅳ collagen （ CⅣ ） in patients with early diabetic nephropathy （DN）. Methods Sixty-four patients with DN in early stage were randomly assigned to the control group （32 cases） and the treatment group （32cases） . Both groups were treated by routine treatment, and with sulfotanshinone sodium injection to the treatment group additionally. The treatment course was 1 month. TGF -β1 and CⅣ were determined with ELISA before and after treatment, and urinary albumin excretion rate （UAER） were examined as well. Results The levels of serum TGF -β1and CⅣ were significantly lower in treatment group after treat- ment than those before treatment （ P 〈0. 01 ） ;and no significant diference of the levels of serum TGF -β1 and C IVwas found in the control group （ P 〉 0. 05 ） . In both groups, The levels of UAER were significantly reduced after treatment than those before treatment （P 〈0. 01 ） , and the descending levels of UAER in treatment group were more significant compared with control group（ P 〈 0. 01 ）. Conclusion Sulfotanshinone sodium injection could decrease the levels of serum TGF -β1 and CⅣ and retard the development of early DN.
出处
《中国实用医药》
2010年第19期7-8,共2页
China Practical Medicine
关键词
丹参酮ⅡA磺酸钠
糖尿病肾病
转化生长因子Β1
Ⅳ型胶原
Sulfotanshinone sodium injection
Diabetic nephropathy
Transforming growth factor-beta 1
Type IV collagen
