摘要
钾离子电流对心肌细胞的复极化过程有着重要的影响,以LuoRudy91模型为基础研究了通过限制钾离子电流最大值来抑制心脏组织中的螺旋波和时空混沌。结果表明:限制钾离子总电流能有效抑制螺旋波和时空混沌;含时和不含时外行钾离子电流之一不被抑制将会增大抑制螺旋波和时空混沌难度。控制机制是:抑制钾离子总电流明显地延长心肌细胞的有效不应期,导致螺旋波和时空混沌不能维持而湮灭。
The potassium current has an important impact on the process of repolarization of myocardial cells. Suppression of spiral waves and spatiotemporal chaos in LuoRudy91 model is considered. The control strategy of restricting the potassium current is applied. Two numerical results are obtained. One is that the spiral wave and spatiotemporal chaos can be effectively suppressed by limiting the total current of potassium. The other is that the suppression of spiral wave and spatiotemporal chaos becomes difficult if one of the time-dependent and time-independent potassium current is not restrained. The control mechanism limiting the total potassium current can significantly prolong the effective refractory period of myocardial cells,lead to the result that spiral waves and spatiotemporal chaos can not be maintained, and thus ,they are annihilated.
出处
《广西师范大学学报（自然科学版）》
CAS
北大核心
2010年第2期5-8,共4页
Journal of Guangxi Normal University:Natural Science Edition
基金
国家自然科学基金资助项目(10765002)
关键词
螺旋波
时空混沌
钾离子电流
spiral wave
spatiotemporal chaos
potassium current
