摘要
目的:研究NC方案治疗转移性乳腺癌的疗效和毒性反应。方法:40例转移性乳腺癌患者接受NC方案化疗,设为化疗组,NC方案,NVB25mg/m2ivgtt,d1、8;DDP70mg/m2ivgtt,d1,21～28d为一周期,4周期为一疗程。对照组患者采用最佳支持治疗。结果:化疗组和对照组有效率分别为45.0%和2.5%,两组比较,有显著性差异(P<0.01);两组中位生存期(MST)分别为21.3个月和12.1个月,两组比较,有显著性差异(P<0.01)。毒性反应方面,化疗组明显高于对照组,但大部分患者可以耐受。结论:转移性乳腺癌患者给予NC方案化疗疗效理想,毒性反应可以耐受,值得临床推广。
Objective：To assess the efficacy and toxicity of the combination of Navelbine and Cisplatin on advanced breast cancer.Methods：40 patients with advanced breast cancer were enrolled into the study.Navelbine 25 mg/m2,ivgtt on day1,8;Cisplatin 70 mg/m2,ivgtt on day 1;the chemotherapy group was repeated every 21-28 days.After four cycles of chemotherapy,the efficacy and toxicity were evaluated.The other 40 patients of the control group adopted the best support able treatment.Results：The efficacy rates of the two groups were 45.0%（chemotherapy group） and 2.5%（control group）,there was a significant difference（P〈0.01）.The median survival time（MST） of the two groups were 21.3 months and 12.1 months,there was a significant difference（P〈0.01）.Most of them were tolerable.Conclusion：The combination of Navelbine and Cisplatin is an effective,well-tolerated scheme in the treatment of advanced breast cancer.It＇s worthy of promotion.
出处
《中国医药导报》
CAS
2010年第19期54-55,共2页
China Medical Herald
关键词
转移性乳腺癌
NC方案
疗效
毒性反应
Advanced breast cancer
Combination of Navelbine and Cisplatin
Efficacy
Toxicity
