摘要
目的探讨原发性肝癌(HCC)的双源CT灌注成像(CTPI)特征及其临床价值。方法对30例HCC患者行CT灌注扫描,获得肝动脉灌注量(ALP)、门静脉灌注量(PVP)、肝动脉灌注指数(HPI)、灌注流量(BF)、血管通透性(P)、patlak血容量(pBV)等灌注参数,以评价HCC的CT灌注特点。结果 (1)HCC的时间-密度曲线(TDC)在动脉期迅速上升至峰值,而后维持平衡或较快下降;(2)30例肿瘤组织在ALP、HPI、BF、P、pBV图上均表现为高灌注,其中的10例ALP图呈均匀高灌注,20例呈不均匀高灌注,坏死区无血流灌注;(3)肿瘤组织ALP、HPI、BF、pBV明显高于瘤旁肝组织和正常肝组织(P<0.05),PVP明显低于瘤旁肝组织和正常肝组织(P<0.05);(4)边缘模糊的瘤灶周围肝组织ALP、BF高于边缘清晰的瘤灶周围肝组织(P<0.05);(5)CT灌注图像测得HCC病灶面积较原始图像所测得的面积大。结论双源CTPI能很好的反映HCC的血流灌注特点,对HCC的诊断和治疗有重要的临床应用价值。
Objective To investigate the dual-source CT perfusion imaging（CTPI） features of hepatocellular carcinoma（HCC） and its clinical value.Methods CT perfusion scans were performed with dual-source CT in 30 HCC patients.Arterial liver perfusion（ALP）,portal venous perfusion（PVP）,hepatic perfusion index（HPI）,blood flow（BF）,perseability（P） and patlak blood volume（pBV） of all HCC lesions were collected and analyzed by body PCT perfusion software build dual-source CT.Results （1） Time-density curve（TDC） of HCC raised and peaked quickly in arterial phase and then the curve stayed unchanged for a time or descended quickly.（2）The tumor tissue demonstrated hyper-perfusion on ALP,HPI,BF,P and pBV map in all cases,of which homogeneous hyper-perfusion was showed in 10 cases and inhomogeneous hyper-perfusion in 20 cases and no blood perfusion in the necrosis tissue.（3）The values of ALP,HPI,BF,pBV were higher,but PVP was lower,in the tumor than those in the tumor-adjacent tissues and the normal liver（P〈0.05）.（4）The values of ALP,BF of the liver tissue around the lesion with a blurring edge were higher than those of the lesions with a clear edge（P〈0.05）.（5）The size of HCC lesions measured on CTPI was larger than that on original CT images.Conclusion Dual-source CTPI can provide much more information about the hemodynamics features of HCC,which is helpful in diagnosing and treating the diseases.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第12期1373-1376,F0002,共5页
Jiangsu Medical Journal
关键词
肝细胞癌
CT灌注成像
Hepatocellular carcinoma
CT perfusion imaging
