摘要
目的研究子宫肌瘤患者雌激素受体（ＥＲ）的改变及其性激素调节。方法应用放射配体结合法和免疫组化法测定子宫肌瘤患者的外周血白细胞和子宫组织中的ＥＲ，同时放免测定血清中性激素的含量。结果子宫肌瘤患者的雌激素和孕激素（Ｅ和Ｐ）水平与对照组相差不显著（Ｐ＞０．０５），而其白细胞ＥＲ水平在围排卵期和黄体期高于对照组（Ｐ＜０．０５），子宫组织中ＥＲ与白细胞ＥＲ呈正相关（Ｒ＝０．９８２，Ｐ＜０．０１），不同数目和大小的子宫肌瘤，其白细胞ＥＲ相差不显著（Ｐ＞０．０５）。白细胞和子宫组织中ＥＲ水平与Ｅ２正相关，与Ｐ负相关（Ｐ＜０．０５）。结论白细胞ＥＲ与子宫组织中ＥＲ是同源的，受相同的遗传基因控制，也受相同的机制（Ｅ和Ｐ）进行调节，测定白细胞ＥＲ可以反映子宫组织中ＥＲ水平。子宫肌瘤的发生并非由Ｅ２的直接升高引起，而可能与ＥＲ的升高有关，ＥＲ加强和放大了Ｅ２的生物效应，长期刺激诱发肌瘤发生。
Objective To study the changes of estrogen receptor (ER) in patients with uterine myoma and its sex hormone regulation. Methods To measure the ER in peripheral white blood cell (WBC) and uterine tissue by radioligand binding method and immuno histochemistry, to measure serum sex hormone concentrations by radioimmunoassay. Results there were no significant difference in serum estrogen and progesterone concentrations between myoma patients and the controls ( P >0.05). The ER level in WBC was higher in myoma patients than in the controls ( P <0.01). There was a positive correlation between ER in uterine tissue and in WBC (r=0.982, P <0.01), and reduced ER in WBC after hysterectomy. No correlation was found between ER in WBC and the number or size of myoma ( P <0.05). ER in WBC and uterine tissue were correlated to estrogen positively and progesterone negatively ( P <0.05). Conclusion ER in WBC and uterine tissue were homologous. They were controlled by the same gene and regulated by the same mechanism estrogen and progesterone. Measurement of ER in WBC could reflect ER in uterus. The development of uterine myoma would be associated with rising of ER but not estrogen. ER could enhance and amplify bioavailability of estrogen, and myoma was caused by this long term effect of ER and estrogen.
出处
《上海医学》
CAS
CSCD
北大核心
1999年第1期45-47,共3页
Shanghai Medical Journal
