摘要
为了比较兰索拉唑每日１５ｍｇ与３０ｍｇ两种剂量口服治疗十二指肠溃疡的效果及安全性，对１０９例经内镜证实活动性十二指肠溃疡随机分成１５ｍｇ组（５１例）和３０ｍｇ组（５８例）。剂量分别为每日１５ｍｇ和３０ｍｇ，疗程２～４周。于疗程结束后重复胃镜检查，２周溃疡愈合率１５ｍｇ组为７０．６％；３０ｍｇ组为８９．７％，３０ｍｇ组明显高于１５ｍｇ组（Ｐ＜０．０５）。４周溃疡愈合率１５ｍｇ和３０ｍｇ组分别为９６．１％和９８．３％，两组比较无明显差异（Ｐ＞０．０５）。３ｄ，７ｄ，１４ｄ的疼痛累积缓解率１５ｍｇ组分别为５５．４％（２２／３９）；８２．１％（３２／３９）；９２．３％（３６／３９）；３０ｍｇ组分别为６８．８％（３３／４８）；９１．７％（４４／４８）；１００％（４８／４８）。两组比较无明显差异（Ｐ＞０．０５）。治疗中两组均未发生明显药物不良反应以及实验室指标的异常。研究结果表明兰索拉唑每日１５ｍｇ，３０ｍｇ均为中国人十二指肠溃疡病安全有效范围，而３０ｍｇ更能促进溃疡的愈合。
In order to compare the efficacy of lansoprazole 15 mg and 30 mg (TAKEDA) daily in the treatment of duodenal ulcer disease, 109 patients with active duodenal ulcer proven by endoscopy randomized to lansoprazole 15 mg and 30 mg daily for 4 weeks. After 2 weeks complete ulcer healing was seen in 70.6% (36/51) of patients given 15 mg and in 89.7% (52/58) given 30 mg (between-group difference P<0.05). At 4 weeks 96.1% (49/51) and 98.3% (57/58) (not significant, P>0.05) respectively. The pain relief rate were 55.4% (22/39),82.1%(32/39) and 92.3% (36/39) by day 3,7, and 14 respectively, as compared with 68.8% (33/48), 91.7% (44/48) and 100% (48/48) of patients with lansoprazole 30 mg. Pronounced improvement in the other gastrointestinal symptoms were similar in both groups. Both treatments were equally well tolerated.Conclusion: 15 mg and 30 mg lansoprazole were shown to be highly effective and well-tolerated treatment for active duodenol ulcer disease in China. While the 30 mg lansoprazole showed a more rapid ulcer healing effect.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1999年第1期22-25,共4页
The Chinese Journal of Clinical Pharmacology
