摘要
目的探讨急性肺损伤（ＡＬＩ）肺组织血小板内皮细胞粘附分子－１（ＰＥＣＡＭ－１）ｍＲＮＡ表达的变化和可能作用。方法在脂多糖（ＬＰＳ）诱发的大鼠ＡＬＩ模型，使用斑点杂交观察肺组织ＰＥＣＡＭ－１ｍＲＮＡ表达的变化。结果正常肺组织表达较高水平的ＰＥＣＡＭ－１ｍＲＮＡ；在ＡＬＩ大鼠肺组织，ＰＥＣＡＭ－１ｍＲＮＡ表达早期下调，但致伤６ｈ时，又基本恢复至正常水平。结论正常肺组织表达较高水平的ＰＥＣＡＭ－１ｍＲＮＡ，ＰＥＣＡＭ－１可能参与ＡＬＩ的发病。
Objective To explore the changes of platelet endothelial cell adhension molecule-1(PECAM-1)mRNA expression and its potential functions in lung with acute lung injury.Methods We measured PECAM-1 mRNA in rat lung with ALI induced by lipopolysaccharide by dot-blot hybridization.Results Normal rat lung expressed PECAM-1 mRNA in higher level, expression of PECAM-1 mRNA was down-regulated early but restored that level in normal rat at 6 hour post-injury in lung.Conclusion Normal lung expresses PECAM-1 mRNA in higher level. PECAM-1 maybe involve in pathogenesis of ALI. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第1期12-13,共2页
Chinese Journal of Critical Care Medicine
关键词
急性
肺损伤
PECAM-1
MRNA
Platelet endothelial cell adhension molecule-1 Expression Acute lung injury
